Fri Dec 29 2023

258 articles - From Friday Dec 22 2023 to Friday Dec 29 2023

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Gastroenterology

AGA Clinical Practice Guideline on the Management of Pouchitis and Inflammatory Pouch Disorders.

This guideline provides a comprehensive, patient-centered approach to the management of patients with pouchitis and other inflammatory conditions of the pouch.

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AGA Clinical Practice Update on Endoscopic Full-Thickness Resection for the Management of Gastrointestinal Subepithelial Lesions: Commentary.

The purpose of this American Gastroenterological Association (AGA) Clinical Practice Update (CPU) is to describe the various techniques for endoscopic full-thickness resection and to facilitate their appropriate application in the management of subepithelial lesions. Methods This CPU was commissioned and approved by the AGA Institute Clinical Practice Updates Committee (CPUC) and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership and underwent internal peer review by the CPUC and external peer review through standard procedures of Gastroenterology.

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Meta-analysis

meta-analyses and systematic reviews

Aliment Pharmacol Ther

Improving primary prophylaxis of variceal bleeding by adapting therapy to the clinical stage of cirrhosis. A competing-risk meta-analysis of individual participant data.

In patients with compensated cirrhosis and high-risk varices on primary prophylaxis, NSBBs significantly improved survival vs EVL, with no additional benefit noted adding EVL to NSBBs. In decompensated patients, survival was similar with both therapies. The study suggests that NSBBs are preferable when advising preventive therapy in compensated patients.

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Am J Gastroenterol

Performance of prediction models for esophageal squamous cell carcinoma in general population: a systematic review and external validation study.

Several prediction models showed moderate performance in external validation and the prediction models may be useful in screening for ESCC. Further research is needed on model optimization, generalization, and implementation, as well as health economic evaluation.

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Hepatology

Letter to the Editor: Diagnostic accuracy of AGILE3+ score for advanced fibrosis in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis.

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Reply: Diagnostic accuracy of AGILE3+score for advanced fibrosis in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Burden of perianal disease in Crohn's disease: Accelerating medical therapy and high rates of perianal surgery over the last four decades - Results from a population-based study over four decades.

The burden of perianal disease and perianal surgery rates were high in this cohort. Therapeutic strategy was accelerated in patients with perianal Crohn's over time with higher exposure to immunosuppressives and biologics. Surgical management of perianal disease remained unchanged amongst the cohorts.

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Clinical trial: Combination allopurinol-thiopurine versus standard thiopurine in patients with IBD escalating to immunomodulators (the DECIDER study).

Thiopurine-allopurinol therapy is safe and mitigates thiopurine adverse effects, thus enhancing tolerability without compromising efficacy (ACTRN12613001347752).

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Dietary index based on the Food Standards Agency nutrient profiling system and risk of Crohn's disease and ulcerative colitis.

A diet with low nutritional quality as measured by the FSAm-NPS-DI Score is associated with a higher risk of CD but not UC.

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Spleen-dedicated stiffness measurement performed well to rule out high-risk varices in HBV-related hepatocellular carcinoma: Screening for high-risk varices in HCC.

We validated that the SSM =40 kPa using a 100-Hz probe could safely eliminate more unnecessary EGDs than the Baveno VI criteria in patients with HBV-related HCC. However, the efficacy of the Baveno VII algorithm in patients with HCC requires further investigation.

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Am J Gastroenterol

AI evaluation of Stool Quality Guides Management of Hepatic Encephalopathy using a Smartphone App.

AI-BSS communications improved insight into self-BSS over time. Dieta-App to gauge stool AI characteristics was acceptable and increased insight into lactulose dose and BSS in cirrhosis.

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Cost-Effectiveness Analysis of HCC Surveillance in Nonalcoholic Fatty Liver Disease Cirrhosis using US Visualization Score C-Triggered Abbreviated MRI.

HCC surveillance using US Visualization score-based approach, using aMRI for Visualization score C, appears to be the most cost-effective strategy in NAFLD cirrhosis patients.

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Determining the accuracy of intestinal ultrasound scores as a pre-screening tool in Crohn's disease clinical trials.

Segmental IUS BWT is highly accurate to detect moderate-to-severe endoscopic inflammation. IUS may be the ideal pre-screening tool to reduce unnecessary trial screen failures.

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EPIDEMIOLOGY, COMORBIDITIES, AND TREATMENT OF CYCLIC VOMITING SYNDROME IN THE UNITED STATES.

This study provides the first population-level estimates of CVS incidence and prevalence in the US. Comorbid conditions are common, and most patients with CVS do not receive adequate treatment. These findings underscore the need for improving disease awareness and developing better screening strategies and effective treatments.

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Efficacy and Safety of Ustekinumab for Ulcerative Colitis Through 4 Years: Final Results of the UNIFI Long-term Maintenance Study.

The long-term efficacy of ustekinumab maintenance in patients with UC was confirmed through 4 years. No new safety signals were observed.

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From Shadows to Spotlight: Exploring the Escalating Burden of Alcohol-Associated Liver Disease and Alcohol Use Disorder in Young Women.

Throughout the last decade, the trend of AUD varied among regions while the impact of ALD has increased, requiring urgent public health strategy to mitigate these complications, particularly in females in Europe and the Asia-Pacific region.

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High incidence rate of CT-measured steatotic liver disease in men with and without HIV infection.

Metabolic factors, but not HIV, were associated with incident SLD. The high IR suggests that SLD will continue to increase in PWH.

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Measuring size of colorectal polyps using a virtual scale endoscope or visual assessment: A randomized controlled trial.

VSE significantly improves the size measurement accuracy of colorectal polyps during colonoscopies compared to VA and results in fewer misclassifications at relevant decision-making size thresholds.

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Potential Cost Savings in Medicare Part D Across Gastroenterology; An Assessment of Alternative Drug Sourcing.

Disproportionate Part D spending likely reflects less competitive acquisition cost. Provider awareness of medications with advantaged price may promote targeted prescribing with potentially tremendous healthcare savings.

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Resectability of Small Duodenal Tumors: A Randomized Controlled Trial Comparing Underwater Endoscopic Mucosal Resection and Cold Snare Polypectomy.

UEMR has superior vertical resectability compared to CSP, but CSP has a shorter procedure time and fewer bleeding events. Although CSP is preferable for most small SNADETs, UEMR should be selected for lesions that cannot be definitively diagnosed as mucosal low-grade neoplasias.

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Tofacitinib in acute severe ulcerative colitis (TACOS): A randomized controlled trial: Tofacitinib in ASUC.

In patients with ASUC, combination of tofacitinib and corticosteroids improved treatment responsiveness and decreased the need for rescue therapy.

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Understanding predictors of fatigue over time in persons with IBD: The importance of depressive and anxiety symptoms.

Anxiety, depression and pain predicted fatigue impact over time in IBD, suggesting that targeting psychological factors and pain for intervention may lessen fatigue burden.

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Utilizing the Diabetes Care System for A County-wide Hepatitis C Elimination: An Integrated Community-based Shared Care Model in Taiwan.

Although HCV prevalence varied, the care cascades achieved consistent results across townships/cities. We have further successfully implemented the model in county-wide hospital-based diabetes clinics, eventually treating 89.6% of the total PwD. A collaborative effort between diabetes care and HCV elimination enhanced the testing and treatment in PwD through an innovative shared care model.

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Variations in practice among cirrhotic patients with portal vein thrombosis and esophageal varices: a North American survey study.

While providers agree on the clinical scenarios that merit initiation of anticoagulation, practice variation was identified in the means of preventing first VH.

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Clin Gastroenterol Hepatol

Age, BMI, and type2 diabetes modify the relationship between PNPLA3 and advanced fibrosis in children and adults with NAFLD.

Age, BMI, and T2DM modify the risk of advanced fibrosis associated with PNPLA3 G-allele. Preventing or reversing T2DM and obesity in persons carrying PNPLA3 G-allele may lower the risk for advanced fibrosis in NAFLD.

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Development of an MRI-based prediction model for anti-TNF treatment failure in perianal Crohn's disease: A multicenter study.

Our risk prediction models consisting of clinical and/or radiologic variables accurately predict treatment failure in patients with PAF.

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Older patients with ACLF have a higher waitlist mortality, but acceptable post-LT survival when compared to younger patients.

Older patients with Est-CLF had significantly higher waitlist mortality than younger patients, but had acceptable 1-year post-LT survival including those with Est-ACLF-3; therefore age alone should not be considered as a contraindication for LT. Older patients with respiratory failure should be carefully selected for LT.

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Prospective comparison of ATI and CAP for liver steatosis diagnosis in patients with NAFLD and type 2 diabetes.

ATI may be used as an alternative to CAP for the diagnosis and quantification of steatosis, in patients with T2D and NAFLD.

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Screening for fibrosis promotes life-style changes. A prospective cohort study in 4,796 individuals.

Screening for liver fibrosis is associated with sustained improvements in alcohol consumption, diet, weight, and exercise in at-risk ALD and MASLD. The changes are most pronounced in screening positive participants, but not limited to this group.

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Smoking and alcohol consumption and risk of incident diverticulitis in women.

In this large prospective study of women, smoking and alcohol consumption were associated with an increased risk of incident diverticulitis. These data highlight additional modifiable risk factors for diverticulitis that may aid in prevention.

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Endosc Int Open

A stag beetle knife can achieve stabler and safer endoscopic submucosal dissection in the esophagus.

Performing esophageal ESD with an SB knife is a safe procedure with less variation in procedure time and less muscule exposure.

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Analysis of adverse events with lumen apposing metal stents for drainage of pancreatic fluid collections.

Endoscopists should be aware of the risk factors for LAMS-related bleeding and tailor their drainage strategy, including utilization of plastic stents for drainage of pseudocysts and adherence to a strict imaging interval and follow-up protocol.

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Antibiotic prophylaxis and post-procedure infectious complications in endoscopic retrograde cholangiopancreatography with peroral cholangioscopy.

No reduction in infectious complication rates and AEs was seen with AP administration for SOC. The continued need for AP in SOC remains uncertain.

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Colorectal serrated lesions and polyps in the Danish population: A large nationwide register-based cohort study.

From 2019 to 2021 the number of SPs seem to stabilize, while the proportion of SSLs keeps rising. Synchronous lesions were common along al subtypes of SP.

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Endoscopic ultrasound-guided perivascular pancreatic radiofrequency ablation using a hydroxyethyl starch solution prior to pancreatectomy.

Preoperative perivascular augmented RFA using HES was safe, and in the pancreatic animal model, the best timeframe was within 24 hours before pancreatic surgery. This technique might improve resectability in selected borderline and locally advanced pancreatic cancers.

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Gastrointestinal bleeding in patients with hereditary hemorrhagic telangiectasia: Long-term results of endoscopic treatment.

Endoscopic treatment of gastrointestinal teleangiectases for gastrointestinal bleeding in patients with HHT is effective in the long term and safe.

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Management of foreign body ingestion in adults: Time to STOP and rethink endoscopy.

Conservative management for patients presenting with recurrent high-risk foreign body ingestion was safe in appropriately selected cases. Re-presentation is common and poses significant challenges for health care providers.

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Repeat bidirectional double-balloon enteroscopy 1 year later may be proper in Peutz-Jeghers patients with difficult-to-reach polyps.

The difficult-to-reach polyps may have a low risk of immediate symptomatic intussusception, possibly due to limited bowel mobility by extraluminal adhesions, and the likelihood of reaching them at repeat DBE was substantial. Hence, repeat DBE 1 year later may be proper in such patients with PJS.

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Utility of gastroscopy in the left lateral semi-recumbent position: A blood-free coup!

These data show that endotherapy in the left lateral semi-recumbent position is feasible, safe, and effective. It should be done when endoscopy in the left lateral decubitus position reveals a pool of blood in the fundus and there is inadequate visualization of the fundus.

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Endoscopy

Gastric Peroral Endoscopic Myotomy versus Botulinum Toxin injection for the treatment of refractory gastroparesis: results of a double-blind randomized controlled study.

G-POEM seems to have higher clinically relevant success rate than BTI, but not statistically demonstrated. Anyway, this study confirms the interest of treatments targeting the pylorus, either mechanically or chemically, for managing refractory gastroparesis.

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Post-colonoscopy colorectal cancers in a national FIT-based CRC screening program.

The 3-year PCCRC rate was low in this FIT-based CRC screening program. Approximately half of PCCRCs were interval PCCRCs. These were mostly caused by missed lesions and were diagnosed at more advanced stage. This emphasizes the importance of high-quality colonoscopy with optimal polyp detection.

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Gastroenterology

A Randomized Controlled Phase 2 Dose-Finding Trial to Evaluate the Efficacy and Safety of Camostat in the Treatment of Painful Chronic Pancreatitis: The TACTIC Study.

We were not able to reject the null hypothesis of no difference in improvements in pain or quality of life outcomes in participants with painful CP who received camostat compared to placebo. Studies are needed to further define mechanisms of pain in CP to guide future clinical trials, including minimizing placebo responses and selecting targeted therapies. (NCT02693093).

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Amitriptyline for the management of IBS in primary care.

If these first-line therapies fail to improve symptoms, neuromodulators such as amitriptyline are recommended as a second-line treatment. However, amitriptyline is infrequently prescribed for the management of IBS in primary care as its efficacy has not previously been studied in this setting.

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Cancer-associated Fibroblast Induces Acinar-to-ductal Cell Transdifferentiation and Pancreatic Cancer Initiation via LAMA5/ITGA4 axis.

Results collectively suggest the first evidence for CAF-influenced acino-ductal phenotypic switchover, thus highlighting tumor micro-environment role in the pancreatic carcinogenesis inception.

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Dysbiosis and associated stool features improve prediction of response to biological therapy in inflammatory bowel disease.

Faecal characterization based on microbial load, moisture content, calprotectin concentration, and enterotyping may aid in the therapeutic choice of biological therapy in IBD.

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Fibroblast-Derived Lysyl Oxidase Increases Oxidative Phosphorylation and Stemness in Cholangiocarcinoma.

Increased LOX is driven by stromal inflammatory cancer-associated fibroblasts and correlates with diminished survival of patients with CCA. Modulating the LOX activity can serve as a novel tumor microenvironment-directed therapeutic strategy in bile duct pathologies.

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Influence of procedural volume on the outcome of gastric endoscopic submucosal dissection: A nationwide population-based study using administrative data.

Procedural volume was closely associated with clinical outcome in patients undergoing ESD for gastric cancer or adenoma.

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Sex, genotype, and liver volume progression as risk of hospitalization determinants in autosomal dominant polycystic liver disease.

Both imaging and clinical genetic scoring have the potential to inform patients about the risk of developing symptomatic disease throughout their lives. The combination of female sex, germline PRKCSH alteration, and rapid TLV-progression is associated with the greatest odds of PLD-related hospitalization.

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Sex-dependent efficacy of dietary fiber in pediatric functional abdominal pain.

Dietary fiber preferentially reduces abdominal pain frequency in boys, highlighting the importance of considering sex in future dietary intervention studies for FAPDs. ClincialTrials.gov number, NCT00526903.

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The environmental Impact of Gastrointestinal Procedures: A Prospective study of Waste Generation, Energy Consumption and Auditing in an Endoscopy Unit.

On average, every 100 GI endoscopy procedures (EGD/ colonoscopy) are associated with 303 kg. of solid waste and 1385 gallons of liquid waste generation, and 1980 kW hour energy consumption. Potentially recyclable materials account for 20% of the total waste. These data could serve as an actionable model for health-systems to reduce total waste generation, decrease landfill waste, and water waste towards environmentally sustainable endoscopy units.

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Gastrointest Endosc

A 19-gauge fine-needle biopsy needle compared with a 22-gauge fine-needle biopsy needle for EUS-guided liver biopsy: a prospective randomized study.

19-gauge FNB liver core biopsies are superior to 22-gauge FNB in terms of length of longest core and aggregate specimen length. There is considerably more fragmentation of the 22-gauge cores during tissue processing. There was no increased post-procedure pain or AEs with the 19-gauge. A 19-gauge FNB is preferred to 22-gauge FNB for EUS-LB.

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Bilevel positive airway pressure ventilation in patients susceptible to hypoxemia during procedural sedation for colonoscopy: A prospective randomized controlled study.

In individuals with OSA or overweight status, the use of BPAP ventilation during colonoscopy significantly reduced the incidence of hypoxemia.

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Biliary Drainage in Hilar and Perihilar Cholangiocarcinoma; 25-Year Experience at a Tertiary Cancer Center.

The relatively higher clinical success of SEMS is countered by the higher stent-specific complication rate. PS can be removed and may better facilitate PTBD. Within PS types, DPTs may have fewer stent-specific AEs. Cases requiring balloon dilation and with endoscopic evidence of pus may benefit from earlier reintervention.

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CLINICAL PREDICTIVE VALUE OF RENALASE IN POST-ERCP PANCREATITIS.

Baseline native renalase levels are very sensitive for predicting PEP. Further studies are needed to determine the potential clinical role of renalase in predicting and preventing PEP.

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Does successful EUS-guided pancreatic cyst chemoablation safely allow reduction in the frequency of radiographic surveillance? Long-term follow-up of randomized prospective data.

The ChARM Post-Treatment Reduced Radiographic Surveillance Protocol safely allows a reduction in radiographic surveillance. A reduction in cost associated with cyst management under the ChARM protocol was shown when compared to management following Fukukoa or ACG guidelines. According to the questionnaire, most patients reported a moderate level of logistical and emotional burden associated with MRI surveillance, and a majority were in favor of reducing the frequency of radiographic surveillance if it can be done without a marked increase in oncologic risk.

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Outcomes of Cold Snare Endoscopic Mucosal Resection of Nonampullary Duodenal Adenomas =1 cm: A Multicenter Study.

This retrospective multicenter study demonstrates that cs-EMR for nonampullary duodenal adenomas is safe and technically feasible with an acceptable recurrence rate. Future prospective studies are needed to directly compare outcomes of cs-EMR with conventional and underwater EMR.

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Post-ERCP Cholecystitis: Incidence, Characteristics, and Outcomes from a Prospective Multi-center Biliary Endoscopy Registry.

Estimates of post-ERCP cholecystitis incidence can inform discussions around procedural risk.

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SAFETY AND TOLERABILITY OUTCOMES OF NON-ANESTHESIOLOGIST-ADMINISTERED PROPOFOL VIA TARGET CONTROLLED INFUSION IN ROUTINE GASTROINTESTINAL ENDOSCOPY.

NAAP via TCI is an effective and safe sedation method for routine endoscopy. Proper propofol dosage based on individual patients and the presence of trained operators are crucial for NAAP sedation management.

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Safety and Efficacy of Direct Percutaneous Endoscopic Jejunostomy Tube Placement Compared with Surgical Jejunostomy: A Tertiary Care Analysis.

DPEJ is a safe and effective alternative to surgical jejunostomy in eligible patients and may be associated with decreased complication rates at 90-days.

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Gut

Endoscopic variceal ligation versus propranolol for the primary prevention of oesophageal variceal bleeding in patients with hepatocellular carcinoma: an open-label, two-centre, randomised controlled trial.

EVL is superior to PPL in preventing initial EVB in patients with HCC. The benefits of EVL on EVB and OS may be limited to patients with BCLC stage A/B and not to those with BCLC stage C/D.

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Gut microbiota predicts severity and reveals novel metabolic signatures in acute pancreatitis.

The orointestinal microbiome predicts clinical hallmark features of AP, and SCFAs may be used for future diagnostic and therapeutic concepts.

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Protein biomarkers and alternatively methylated cell-free DNA detect early stage pancreatic cancer.

A combined panel of circulating markers including proteins and methylated cfDNA increased discrimination compared with CA19-9 alone for early stage PDAC.

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Specific gut pathobionts escape antibody coating and are enriched during flares in patients with severe Crohn's disease.

Distinct gut bacterial IgG2-coating was demonstrated in patients with severe CD and during disease flares. Co-occurrence of non-coated pathobionts with IgG2-coated bacteria points to an uncontrolled inflammatory condition in severe CD mediated via escape from antibody coating by two gut pathobionts.

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Targeting MMP9 in CTNNB1 mutant hepatocellular carcinoma restores CD8+ T cell-mediated antitumour immunity and improves anti-PD-1 efficacy.

Objective The gain of function (GOF) CTNNB1 mutations (CTNNB1 HCC.

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Hepatology

Adjuvant and neoadjuvant therapies for hepatocellular carcinoma.

Moreover, major pathological responses reported from early phase 2 data in the neoadjuvant setting provide a strong rational for the evaluation of these concepts in phase 3 trials. In this review, we summarize current evidence and outline future directions for systemic therapies in early-stage hepatocellular carcinoma.

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Artificial intelligence scoring of liver biopsies in a phase ii trial of semaglutide in non-alcoholic steatohepatitis.

ML categorical assessments reproduced pathologists' results of histological improvement with semaglutide for steatosis and disease activity. ML-based continuous scores demonstrated an antifibrotic effect not measured by conventional histopathology.

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Association of glucagon-like peptide-1 receptor agonists with serious liver events among patients with type 2 diabetes: A scandinavian cohort study.

Use of GLP-1 receptor agonists was associated with a significantly reduced risk of serious liver events, driven by a reduction of compensated and decompensated cirrhosis.

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Combined use of the CLivD score and FIB-4 for prediction of liver-related outcomes in the population.

The CLivD score is a valid tool for LRO risk assessment and improves the predictive performance of FIB-4. The combined use of CLivD and FIB-4 identified a subgroup where 1 in 3 individuals developed LROs within 10 years.

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Decreased platelet activation predicts hepatic decompensation and mortality in patients with cirrhosis.

Preserved PAR-1- and PAR-4-inducible platelet activation was linked to a lower risk of decompensation and death. In contrast, higher epinephrine-inducible platelet activation was a risk factor for thromboembolism and PVT.

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Defining an approach for therapeutic strategies in metabolic dysfunction-associated steatotic liver disease after liver transplantation.

Despite the oversized clinical burden of MASLD among LT recipients, there is currently a lack of regulatory approach and pathway for therapeutics development in this patient population. The present document, thus, provides guidance for therapeutics development that incorporates nuances of transplant care in patients with post-LT MASLD to facilitate drug development.

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Effects of trientine and penicillamine on intestinal copper uptake: A mechanistic 64Cu PET/CT study in healthy humans.

In this mechanistic study, we show that TRI inhibits intestinal copper absorption, in addition to its cupriuretic effect. In contrast, PEN has modest effects on the intestinal absorption. This may explain why TRI and PEN are equally effective although urinary copper excretion is lower with TRI. The study questions whether the same therapeutic targets for 24-hour urinary excretion apply to both drugs.

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Event-free survival of maralixibat-treated patients with Alagille syndrome compared to a real-world cohort from GALA.

This study demonstrates a novel application of a robust statistical method to evaluate outcomes in long-term intervention studies where placebo comparisons are not feasible, providing wide application for rare diseases. This comparison with real-world natural history data suggests that maralixibat improves EFS in patients with ALGS.

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Inborn errors of type I interferon immunity in patients with symptomatic acute hepatitis E.

Our results highlight the essential role of type I interferon in preventing symptomatic acute hepatitis E.

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Metabolic dysfunction associated steatotic liver disease and the heart.

Regarding treatment and given the strong co-occurrence of MASLD and asCVD, pharmacotherapy in development for advanced stages of MASLD would ideally also reduce cardiovascular events, as has been demonstrated for T2DM treatments. Given the common drivers, potential causal factors and especially given the increased rate of cardiovascular events, comprehensive cardiometabolic risk management is warranted in patients with MASLD, preferably in a multidisciplinary approach.

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Portable hypothermic oxygenated machine perfusion for organ preservation in liver transplantation (PILOTTM): A randomized, open-label, clinical trial.

HMP-O2 demonstrates safety and noninferior efficacy for liver graft preservation in comparison to SCS. EAD by L-GrAFT7 was lower in HMP-O2, suggesting improved early clinical function. Recipients of HMP-O2 livers also demonstrated a lower incidence PNF and biliary strictures, although this difference did not reach significance.

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Prevalence, distribution and hepatic fibrosis burden of the different subtypes of steatotic liver disease in primary care settings.

Almost al the NAFLD patients met the new criteria for MASLD. The fibrosis burden of the MetALD group was higher than those of the MASLD and ALD groups.

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Seladelpar treatment reduces interleukin-31 and pruritus in patients with primary biliary cholangitis.

Seladelpar decreased serum IL-31 and bile acids in PBC patients. The reductions of IL-31 and bile acids correlated closely with each other and pruritus improvement suggesting a mechanism to explain seladelpar's anti-pruritic effects.

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Sumoylation of methionine adenosyltransferase alpha 1 promotes mitochondrial dysfunction in alcohol-associated liver disease.

Taken together, our findings demonstrate an essential role for SUMOylation of MATa1 K48 for interaction with PIN1 in ALD. Preventing MATa1 K48 SUMOylation may represent a potential treatment strategy in ALD.

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m6A-mediated gluconeogenic enzyme PCK1 upregulation protects against hepatic ischemia-reperfusion injury.

Our study found that activation of the METTL3/m6A-PCK1-gluconeogenesis axis is required to protect against hepatic I/R injury, providing potential intervention approaches for alleviating hepatic I/R injury during liver surgery.

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J Hepatol

A new clinical and prognostic characterization of the patterns of decompensation of cirrhosis.

In almost 50% outpatients the first decompensation is a NAD, which is associated with a decreased survival than patients with ND. Patients who develop NAD must be treated with extreme care and monitored closely to prevent any development of AD. Impact and implications This multicenter study is the first to investigate the role of NAD in patients with cirrhosis. In fact, while the unfavorable impact of AD is well known, NAD is currently a phenomenon existing in clinical practice but never studied. Our data show that almost half of the decompensations in patients with cirrhosis are attributable to NAD and that this involves a higher risk of mortality compared to compensated patients. This study has important clinical implications because it highlights the need to carefully consider patients who develop NAD, in order to prevent further decompensation and reduce mortality.

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An open-label randomised-controlled trial of azathioprine vs. mycophenolate mofetil for the induction of remission in treatment-naive autoimmune hepatitis.

In patients with treatment-naive AIH, MMF with prednisolone achieved a significantly higher rate of biochemical remission at 24 weeks compared to azathioprine combined with prednisolone. Azathioprine use was associated with more (serious) adverse events leading to cessation of treatment, suggesting superior tolerability of MMF. Impact and implications This randomised controlled trial directly compares azathioprine and mycophenolate mofetil (MMF), both in combination with prednisolone, for the induction of biochemical remission in treatment-naive patients with autoimmune hepatitis (AIH). Achieving complete remission is desirable to prevent disease progression. Patients assigned to the MMF group reached biochemical remission more often and experienced fewer adverse events. The findings in this trial may contribute to the re-evaluation of international guidelines for the standard of care in treatment-naive patients with AIH.

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Effects of tetrathiomolybdate on copper metabolism in healthy volunteers and in patients with Wilson disease.

While we did not show an increase in biliary excretion of 64 Cu following TTM administration, we demonstrated that TTM effectively inhibited most intestinal 64 Cu uptake and retained 64 Cu in the blood stream, limiting 64 Cu exposure to organs like the liver and the brain. Impact and implications Bis-choline tetrathiomolybdate (TTM) is an investigational copper chelator for treatment of Wilson Disease. In animal studies of Wilson Disease models, TTM has been shown to facilitate biliary copper excretion. In the present human study, TTM surprisingly did not facilitate biliary copper excretion but instead reduced intestinal copper uptake to a clinically significant degree. Our study improves the understanding of human copper metabolism and the mechanism of action of TTM. Clinical trial number Data is presented from two clinical trials Absorption study EudraCT 2020-005832-31Excretion study EudraCT 2021-000102-25.

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Efficient formation and maintenance of humoral and CD4 T cell immunity targeting the viral capsid in acute-resolving hepatitis E infection.

The viral capsid is the main target of HEV-specific CD4 T cells and antibodies in acute resolving infection, correlating with efficient neutralization of nHEV. Capsid-specific immunity rapidly emerges followed by a stepwise contraction for several years after infection.

Pubmed   Journal   ReadQx 

Episodic overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunt does not increase mortality in patients with cirrhosis.

Episodic OHE after TIPS is not associated with mortality in patients undergoing TIPS, regardless of the indication. Impact and implications Overt hepatic encephalopathy (OHE) is a common complication in patients with advanced liver disease and it is particularly frequent following transjugular intrahepatic portosystemic shunt (TIPS) placement. In cirrhotic patients outside the setting of TIPS, the development of OHE negatively impacts survival, regardless of the severity of cirrhosis or the presence of acute on chronic liver failure. With this multicenter, non-inferiority observational study we demonstrated that post-TIPS OHE does not increase the risk of mortality in patients undergoing TIPS, irrespective of the indication. This finding alleviates concerns regarding the weight of this complication after TIPS. Thus, intensive research of factors improving patient selection, and allowing risk stratification remains crucial to ameliorate the quality of life of patients and caregivers and to avoid undermining the positive effects on survival in patients undergoing TIPS.

Pubmed   Journal   ReadQx 

Hepatic prohibitin 1 and methionine adenosyltransferase a1 defend against primary and secondary liver cancer metastasis.

We have identified an PHB1/MAT1A-MAFG/FOSB-MMP-7 axis that controls primary liver cancer metastasis and sensitization to CRLM.

Pubmed   Journal   ReadQx 

Long-term use of tenofovir disoproxil fumarate increases fracture risk in elderly patients with chronic hepatitis B.

The risk of fracture increased with TDF treatment for =24 months in elderly patients with CHB. Selection of nucleos(t)ide analogues should be individualised based on age and comorbidities. Impact and implications Previous literature suggested that the use of tenofovir disoproxil fumarate (TDF) is associated with a decrease in bone mineral density. However, data on the impact of TDF on long-term incident clinical fracture remains scarce. In this real-world territory-wide study of 41,531 treated patients with chronic hepatitis B in Hong Kong, patients who received TDF were associated with a higher risk of fracture after two years of treatment as compared to those who received entecavir. Given the ageing population of patients with chronic hepatitis B with a rising prevalence of comorbidities, our findings support the current treatment guidelines on selection of antiviral treatment based on age and comorbidities.

Pubmed   Journal   ReadQx 

Preventing liver disease with policy measures to tackle alcohol consumption and obesity: the HEPAHEALTH II study.

Policy measures tackling primary risk factors for CLD and liver cancer, such as the implementation of an MUP of €1 and/or an MUP of €0.70 plus SSB tax could markedly reduce the number of Europeans with CLD or liver cancer.

Pubmed   Journal   ReadQx 

Safety and efficacy of the oral TLR8 agonist selgantolimod in individuals with chronic hepatitis B under viral suppression.

Oral selgantolimod up to 3 mg once weekly for 24 weeks was generally safe and well tolerated and led to serologic changes associated with progression to durable cure in two individuals by week 48. Clinicaltrials Gov identifier NCT03491553. Impact and implications The only robust criterion for stopping treatment in chronic hepatitis B is loss of hepatitis B surface antigen (known as functional cure), which is rare during nucleos(t)ide analogue therapy. It is likely that novel antiviral and immunomodulatory therapies will be needed to achieve finite functional cure. Selgantolimod is an oral Toll-like receptor 8 agonist that has shown antiviral activity in vitro as well as safety in a phase I clinical trial with weekly dosing. In this phase II study, selgantolimod therapy was associated with transient increases in serum cytokines, rapid redistribution of circulating immune cell subsets, modest reductions in HBsAg and HBeAg levels, and occasional loss of HBsAg (5%) and HBeAg (16%) among participants with chronic hepatitis B on nucleos(t)ide analogue therapy with viral suppression. Our results support continued development of selgantolimod as a component of a future hepatitis B cure regimen.

Pubmed   Journal   ReadQx 

Tailoring allocation policies and improving access to pediatric liver transplantation over a 16-year period.

In Italy, continuous adaption of pediatric organ allocation policies has produced a unique allocation model. National organ exchange organisation, pediatric prioritisation rules and mandatory-split policy are key factors to maximise the use of donors for pediatric candidates and to minimise WL mortality without compromising outcomes. Impact and implications Children candidate to pediatric liver transplantation still suffers of high mortality worldwide. During the last decades, in Italy a continuous adaption of organ allocation policies has produced excellent outcomes for children awaiting liver transplantation. The mortality rate of pediatric liver transplant candidates has been minimized to almost zero, mainly using grafts from deceased-donors. Pediatric priorization rules, national organ exchange organization and mandatory-split liver policy resulted in a unique allocation model for pediatric liver transplantation candidates and represent a landmark for the pediatric transplant community.

Pubmed   Journal   ReadQx 


Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

AP&T: Editors' declarations of interest.

Pubmed   Journal   ReadQx 

Editorial: Antibiotics as a risk factor for irritable bowel syndrome.

Pubmed   Journal   ReadQx 

Editorial: Bile acid diarrhoea - simplified clinico-biochemical diagnosis.

Pubmed   Journal   ReadQx 

Editorial: Does knowledge about liver disease enhance adherence to lifestyle recommendations?

Pubmed   Journal   ReadQx 

Editorial: Gastroenterologists should definitely draw closer attention to psychosocial comorbidities.

Pubmed   Journal   ReadQx 

Editorial: Is there a relationship between dysphagia, chest pain and mucosal innervation in patients with oesophageal motility disorders?

Pubmed   Journal   ReadQx 

Editorial: Monitoring methotrexate polyglutamates in Crohn's disease.

Pubmed   Journal   ReadQx 

Editorial: Moving towards prognostic endoscopic scoring in IBD.

Pubmed   Journal   ReadQx 

Editorial: Resmetirom - a promising treatment option for NASH and liver fibrosis.

Pubmed   Journal   ReadQx 

Editorial: Tenofovir disoproxil fumarate, more than an antiviral drug-Another piece of the puzzle.

Pubmed   Journal   ReadQx 

Editorial: The evolving paradigms and treatments for primary biliary cholangitis.

Pubmed   Journal   ReadQx 

Editorial: Unmasking the silent threat-acute kidney injury in alcohol-associated hepatitis.

Pubmed   Journal   ReadQx 

Implications of the new nomenclature of steatotic liver disease and definition of metabolic dysfunction-associated steatotic liver disease.

The new nomenclature is both a challenge, given the need for dissemination and education across the spectrum of stakeholders, and an opportunity to bring everyone together and spark new research to better understand epidemiology, natural history, diagnosis, biomarkers and management strategies across the spectrum of SLD.

Pubmed   Journal   ReadQx 

Review article: Emerging insights into the epidemiology, pathophysiology, diagnostic and therapeutic aspects of eosinophilic oesophagitis and other eosinophilic gastrointestinal diseases.

Unmet needs for research are dramatically different for EoE and non-EoE EGIDs. In EoE, non-invasive diagnostic tests, clinicopathologic models that determine the risk of disease progression and therapeutic failure, and novel biologic therapies are emerging. In contrast, in non-EoE EGIDs, epidemiologic trends, diagnostic histopathologic thresholds, and natural history models are still developing for these more rare disorders.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Birth cohort colorectal cancer (CRC): implications for research and practice.

We also outline implications of birth cohort CRC for epidemiologic and translational research, as well as current clinical practice. We postulate that recognition of birth cohort CRC as an entity - including and extending beyond rising EOCRC - can advance understanding of risk factors, etiologies, and mechanisms, and address the public health consequences of changing CRC epidemiology.

Pubmed   Journal   ReadQx 

Blue Notes.

Pubmed   Journal   ReadQx 

Impostor Phenomenon and Microaggressions in Gastroenterology: Exposing the Tip of the Iceberg.

Pubmed   Journal   ReadQx 

LIVER RELATED EVENTS IN NASH (MASH): FROM SUBGROUP STRATIFICATION TO INDIVIDUAL RISK PREDICTION.

Pubmed   Journal   ReadQx 

The Evolving Role of Artificial Intelligence in Gastrointestinal Histopathology: An Update.

We describe several current needs within the world of gastrointestinal histopathology, and outline, using currently studied models, how AI can potentially address them. We also highlight pitfalls as AI makes inroads into clinical practice.

Pubmed   Journal   ReadQx 

Endosc Int Open

Are real-world data studies on bowel preparation for colonoscopy necessary? Aren't RCTs enough?

Pubmed   Journal   ReadQx 

Reading capsule endoscopy: Why not AI alone?

Pubmed   Journal   ReadQx 

Gastrointest Endosc

"AI for the new GI": What role does artificial intelligence have in early colonoscopy training?

Pubmed   Journal   ReadQx 

Acidification of the esophagus in post-POEM achalasia patients: all that glitters is not gold.

Pubmed   Journal   ReadQx 

Pancreas lesion size and EUS-guided tissue sampling.

Pubmed   Journal   ReadQx 

Percutaneous coronary intervention and GI hemorrhage: need for accurate predictors of the link to rebleeding.

Pubmed   Journal   ReadQx 

Gut

Early-life exposures and the microbiome: implications for IBD prevention.

Considering the emerging concept of IBD prevention, we propose strategies to minimise maternal and offspring exposure to potentially harmful variables and recommend protective measures during pregnancy and the postpartum period. This holistic view of early-life factors and microbiome signatures among mothers and their offspring will help frame our current understanding of their importance towards IBD pathogenesis and frame the roadmap for preventive strategies.

Pubmed   Journal   ReadQx 

J Hepatol

Adipose Tissue Macrophage Dysfunction in Human MASLD - Cause or Consequence?

Pubmed   Journal   ReadQx 

Advocating for the Implementation of the New Nomenclature for Steatotic Liver Disease: A Call to Action for the National Associations.

Pubmed   Journal   ReadQx 

Battle of the Biopsies: Role of tissue and liquid biopsy in hepatocellular carcinoma.

The early results from multianalyte liquid biopsy panels are promising and suggest they could play a transformative role in HCC detection and management, however, comprehensive clinical validation is still ongoing. In this review, we explore the challenges and potential of both tissue and liquid biopsy, highlighting that these diagnostic methods, while distinct in their approaches, are set to jointly reshape the future of HCC management.

Pubmed   Journal   ReadQx 


Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

American College of Gastroenterology Monograph on Microbiome Therapeutics.

Pubmed   Journal   ReadQx 

Cough With a Pop: A Rare Case of Acquired Abdominal Intercostal Hernia.

Pubmed   Journal   ReadQx 

Cystoid macular edema after initiation of ozanimod for ulcerative colitis.

Pubmed   Journal   ReadQx 

Efficacy and Practical Implementation of Fecal Microbiota Spores, Live-BRPK: A Novel Approach for Preventing Recurrent Clostridioides difficile Infection.

Pubmed   Journal   ReadQx 

Emerging Noninfectious Indications for Live Biotherapeutic Products in Gastroenterology.

Pubmed   Journal   ReadQx 

Future Microbiome Therapeutics for Clostridioides difficile Infection.

Pubmed   Journal   ReadQx 

Non-prescription Therapeutics.

Pubmed   Journal   ReadQx 

Prescription Microbiome Therapeutic for Recurrent Clostridioides difficile Infection: Fecal Microbiota Live-jslm.

Pubmed   Journal   ReadQx 

The Current and Future State of Microbiome Therapeutics in Liver Disease.

Pubmed   Journal   ReadQx 

The Gut Microbiome: A Primer for the Clinician.

Pubmed   Journal   ReadQx 

Use of Impedance Planimetry in the Diagnosis of Gastric Sleeve Stenosis: The Establishment of New Benchmark Values.

Pubmed   Journal   ReadQx 

Utility of abdominal ultrasound in the preoperative diagnosis of appendiceal goblet cell adenocarcinoma.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Cholangitis induced by immune checkpoint inhibitors: analysis of pharmacovigilance data.

Pubmed   Journal   ReadQx 

Eosinophil Distribution in Eosinophilic Esophagitis and its Impact on Disease Activity and Response to Treatment.

Pubmed   Journal   ReadQx 

Eosinophil Involvement Outside the Esophagus in Eosinophilic Esophagitis.

Pubmed   Journal   ReadQx 

Evidence-Based Approach to the Management of Mild Crohn's Disease.

Pubmed   Journal   ReadQx 

Fecal Urgency in Ulcerative Colitis: Impact on Quality of Life and Psychological Well-being in Active and Inactive Disease States.

Pubmed   Journal   ReadQx 

Interim Analysis of a Trial Evaluating the Utility of Non-Targeted Biopsies for Colorectal Neoplasia Detection in Inflammatory Bowel Disease.

Pubmed   Journal   ReadQx 

Meeting Summary: AGA Roundtable on Clinical Trial Design in Inflammatory Bowel Disease.

Pubmed   Journal   ReadQx 

Optimizing Electronic Health Record Use in the Busy Gastroenterology Practice.

Pubmed   Journal   ReadQx 

Per- and poly-fluoroalkyl substances (PFAS) exposure is associated with later occurrence of inflammatory bowel disease.

Pubmed   Journal   ReadQx 

Tofacitinib is effective in treating refractory immune checkpoint inhibitor hepatitis.

Pubmed   Journal   ReadQx 

Endoscopy

A collaborative application for characterizing colorectal lesions could improve quality of tumor resection.

Pubmed   Journal   ReadQx 

A novel dedicated nonslip short-length balloon catheter for treating hepaticojejunostomy anastomotic stricture in balloon enteroscopy-assisted ERCP.

Pubmed   Journal   ReadQx 

A syringe method for esophageal Lugol's iodine chromoendoscopy.

Pubmed   Journal   ReadQx 

Cholangioscopy-assisted endoscopic mucosal resection for bile duct lesions through papillary support: A pilot exploration for super minimally invasive surgery in a porcine model.

Pubmed   Journal   ReadQx 

Cholangioscopy-assisted partial stent-in-stent method useful for bilateral biliary drainage of hilar cholangiocarcinoma.

Pubmed   Journal   ReadQx 

Cold snare endoscopic mucosal resection for colonic polyps: addressing methodological critiques and enhancing future discussions.

Pubmed   Journal   ReadQx 

Comments on "Endoscopic papillectomy for ampullary lesions in patients with familial adenomatous polyposis compared with sporadic lesions: a propensity score-matched cohort".

Pubmed   Journal   ReadQx 

Comments on "No-touch endoscopic full-thickness resection technique for gastric gastrointestinal stromal tumors".

Pubmed   Journal   ReadQx 

Covered self-expandable metal stent for hemostasis of ruptured pseudoaneurysm caused by partial stent-in-stent method.

Pubmed   Journal   ReadQx 

Does endoprosthesis design impact bleeding risk when using lumen-apposing metal stents for drainage of pancreatic fluid collections?

Pubmed   Journal   ReadQx 

Endoscopic closure of a refractory urethroanal fistula using an innovative wound closure device.

Pubmed   Journal   ReadQx 

Endoscopic esophageal cicatricotomy assisted by submucosal injection for the treatment of esophageal stenosis after endoscopic submucosal dissection.

Pubmed   Journal   ReadQx 

Endoscopic submucosal dissection for a small high grade intraepithelial neoplasia in the hypopharynx detected incidentally by artificial intelligence.

Pubmed   Journal   ReadQx 

Endoscopic ultrasound-guided gastrojejunopexy using an improvised T-anchor for successful endoscopic gastrojejunostomy.

Pubmed   Journal   ReadQx 

Endoscopy E-Videos - recently published.

Pubmed   Journal   ReadQx 

Establishing ground truth of polyp size, morphology, and volume using three-dimensional scanning.

Pubmed   Journal   ReadQx 

Magnet-assisted endoscopic removal of ingested sewing needles from the stomach and descending duodenum.

Pubmed   Journal   ReadQx 

Methodological issues in the evaluation of cold snare endoscopic mucosal resection for colon polyps.

Pubmed   Journal   ReadQx 

Misidentification of a duodenal neuroendocrine tumor as an adenoma, with subsequent attempted resection by cold snare polypectomy.

Pubmed   Journal   ReadQx 

Navigating the path to patient safety in endoscopy…going beyond the procedure!

Pubmed   Journal   ReadQx 

Novel strategy of hold-and-drag clip closure with mantis-like claw for post-gastric endoscopic submucosal dissection defect of <30 mm.

Pubmed   Journal   ReadQx 

Novel use of a colonic intraprocedural cleansing device for upper gastrointestinal bleeding.

Pubmed   Journal   ReadQx 

Omental patch-assisted endoscopic closure of the transmural defect after endoscopic removal of a 40-mm gastric gastrointestinal stromal tumor.

Pubmed   Journal   ReadQx 

Radial incision and cutting for post-esophageal endoscopic submucosal dissection stricture with prior perforation during dilation.

Pubmed   Journal   ReadQx 

Rescue technique after endoscopic ultrasound-guided hepaticogastrostomy stent dislocation.

Pubmed   Journal   ReadQx 

Successful closure of gastric wall defect after endoscopic full-thickness resection using novel anchor pronged clips: a case report.

Pubmed   Journal   ReadQx 

Successful removal of a migrated plastic stent using a new endoscopic sheath.

Pubmed   Journal   ReadQx 

Surgical salvage intervention for a migrated metal stent during endoscopic ultrasound-guided hepaticogastrostomy.

Pubmed   Journal   ReadQx 

The "coupler" technique for endoscopic removal of a threaded inside stent that migrated above tight hilar strictures.

Pubmed   Journal   ReadQx 

Tip-in underwater endoscopic mucosal resection for a residual lower rectal lesion extending to the dentate line.

Pubmed   Journal   ReadQx 

Use of disposable endoscope for variceal sclerotherapy.

Pubmed   Journal   ReadQx 

Welcome to ESGE at 60 years.

Pubmed   Journal   ReadQx 

Gastroenterology

A comparison of large language model versus manual chart review for extraction of data elements from the electronic health record.

Pubmed   Journal   ReadQx 

An Unusual Cause of Ascites in a Patient with Hepatitis B.

Pubmed   Journal   ReadQx 

Impostor Phenomenon and Microaggressions in Gastroenterology: Exposing the Tip of the Iceberg.

Pubmed   Journal   ReadQx 

Pharmacotherapy in managing alcohol-use disorder.

Pubmed   Journal   ReadQx 

RNA-based Stool Molecular Testing - a Novel Potential Option for Colorectal Cancer Screening.

Pubmed   Journal   ReadQx 

Unusual Cause of Small Bowel Obstruction in an Elderly Patient.

Pubmed   Journal   ReadQx 

Gastrointest Endosc

An unsuspected cause of obstructive jaundice in an infant.

Pubmed   Journal   ReadQx 

Argon plasma coagulation for snare embedding in the pancreatic duct.

Pubmed   Journal   ReadQx 

Ascaris lumbricoides in the appendicular orifice.

Pubmed   Journal   ReadQx 

Bleeding large duodenal lipoma.

Pubmed   Journal   ReadQx 

Capsule endoscopy successfully diagnosed small intestinal ascariasis which had been misdiagnosed repeatedly.

Pubmed   Journal   ReadQx 

Endoscopic removal of ascaris lumbricoides from colon lumen (with video).

Pubmed   Journal   ReadQx 

Modified Double Wire Technique for Deep Cannulation of Dorsal Duct in Incomplete Pancreas Divisum.

Pubmed   Journal   ReadQx 

Modifying the Sengstaken-Blakemore Tube to Treat Variceal Bleed.

Pubmed   Journal   ReadQx 

Radiographic and Endoscopic Findings of Checkpoint Inhibitor Cholangitis.

Pubmed   Journal   ReadQx 

Top Tips: Endoscopic Retrograde Appendicitis Therapy.

Pubmed   Journal   ReadQx 

Gut

Clinical applications of circulating HBV RNA as a potential surrogate biomarker for intrahepatic cccDNA transcriptional activity.

Pubmed   Journal   ReadQx 

ForePass endoscopic bypass device for obesity and insulin resistance-metabolic treatment in a swine model.

Pubmed   Journal   ReadQx 

Rare complication of peptic ulcer disease.

Pubmed   Journal   ReadQx 

Unexpected finding on surveillance colonoscopy.

Pubmed   Journal   ReadQx 

Hepatology

Edson Lee Forker.

Pubmed   Journal   ReadQx 

February 2024 Hepatology Highlights.

Pubmed   Journal   ReadQx 

From NAFLD to MASLD: Promise and pitfalls of a new definition†.

Pubmed   Journal   ReadQx 

From pain to gain: Leveraging acetaminophen in hepatocyte transplantation for phenylketonuria.

Pubmed   Journal   ReadQx 

HDV screening in chronic HBV: An unmet need of growing importance.

Pubmed   Journal   ReadQx 

Hepatitis B surface antigen seroclearance is uncommon but durable in the long run.

Pubmed   Journal   ReadQx 

Introducing W. Ray Kim, MD, our 2024 AASLD president.

Pubmed   Journal   ReadQx 

Letter to the Editor: Halting antiviral therapy in patients with cirrhosis and chronic hepatitis B: A dangerous game?

Pubmed   Journal   ReadQx 

Letter to the Editor: How F to S turned the premature to be mature?

Pubmed   Journal   ReadQx 

Letter to the Editor: Improving access to transient elastography data for real-world prognostic applications in primary biliary cholangitis.

Pubmed   Journal   ReadQx 

Letter to the Editor: Intratumor fibrotic HCC, a subtype matching the Hoshida S1 subclass?

Pubmed   Journal   ReadQx 

Letter to the Editor: More on Non-Alcohol/Non-Metabolic Dysfunction-Associated Steatohepatitis.

Pubmed   Journal   ReadQx 

Letter to the Editor: The Hepa 1-6 may not be suitable for use in hepatocellular carcinoma models to explore responses to drug therapy.

Pubmed   Journal   ReadQx 

Letter to the editor: Scavenger receptor a is a major homeostatic regulator that restrains drug-induced liver injury.

Pubmed   Journal   ReadQx 

Navigating liver disease complexity: Innovations in in vitro modeling and precision medicine.

Pubmed   Journal   ReadQx 

REPLY: Intratumor fibrotic HCC, a subtype matching the Hoshida S1 subclass?

Pubmed   Journal   ReadQx 

Reply: 'From NAFLD to MASLD: Promise and pitfalls of a new definition'†.

Pubmed   Journal   ReadQx 

Reply: Halting antiviral therapy in patients with cirrhosis and chronic hepatitis B: A dangerous game?

Pubmed   Journal   ReadQx 

Reply: Improving access to transient elastography data for Real-World Prognostic Applications in primary biliary cholangitis.

Pubmed   Journal   ReadQx 

Reply: The Hepa 1-6 may not be suitable for use in hepatocellular carcinoma models to explore responses to drug therapy.

Pubmed   Journal   ReadQx 

Steatotic liver disease, a useful construct in primary care that doesn't upset the apple cart.

Pubmed   Journal   ReadQx 

The hidden face of preemptive tips.

Pubmed   Journal   ReadQx 

The relation of host genetics and symptomatic hepatitis E.

Pubmed   Journal   ReadQx 

J Hepatol

In memoriam Gustav Paumgartner.

Pubmed   Journal   ReadQx 


Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

A Message from the Editors.

Pubmed   Journal   ReadQx 

Editorial: Does knowledge about liver disease enhance adherence to lifestyle recommendations? Authors' reply.

Pubmed   Journal   ReadQx 

Editorial: Monitoring methotrexate polyglutamates in Crohn's disease-Authors' reply.

Pubmed   Journal   ReadQx 

Editorial: Tenofovir disoproxil fumarate more than an antiviral drug-Another piece of the puzzle. Authors' reply.

Pubmed   Journal   ReadQx 

Editorial: The evolving paradigms and treatments for primary biliary cholangitis-Authors' reply.

Pubmed   Journal   ReadQx 

Editorial: Unmasking the silent threat-acute kidney injury in alcohol-associated hepatitis. Authors' reply.

Pubmed   Journal   ReadQx 

Letter: Are we forgetting the importance of steatosis in steatotic liver disease?

Pubmed   Journal   ReadQx 

Letter: Are we forgetting the importance of steatosis in steatotic liver disease? Authors' reply.

Pubmed   Journal   ReadQx 

Letter: Comparing first-line infliximab and vedolizumab for ulcerative colitis-it depends on how you use the drug.

Pubmed   Journal   ReadQx 

Letter: Estimating the incidence of HBsAg seroclearance after cessation of tenofovir and entecavir - potential influence of censored observation.

Pubmed   Journal   ReadQx 

Letter: Estimating the incidence of HBsAg seroclearance after cessation of tenofovir and entecavir-potential influence of censored observation. Authors' reply.

Pubmed   Journal   ReadQx 

Letter: antibiotics prescription and new-onset irritable bowel syndrome.

Pubmed   Journal   ReadQx 

Letter: interpretation of the BESST trial in the context of baseline antidepressant and neuromodulator use-Authors' reply.

Pubmed   Journal   ReadQx 

Letter: interpretation of the BESST trial in the context of baseline antidepressant and neuromodulator use.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Association of Biologics and Small Molecules with MACE: Critical appraisal of included literature matters.

Pubmed   Journal   ReadQx 

Bile acid diarrhea in microscopic colitis.

Pubmed   Journal   ReadQx 

Chronic Hepatitis B and Steatotic Liver Disease: A Blessing in Disguise?

Pubmed   Journal   ReadQx 

Eosinophilic esophagitis: seeing only the tip of the iceberg.

Pubmed   Journal   ReadQx 

This Letter to the Editor is in response to: Prevalence of Nonalcoholic Fatty Liver Disease in Patients With Rheumatoid Arthritis: A Systematic Review and Meta-analysis. Clinical Gastroenterology and Hepatology by Zamani M, etal.

Pubmed   Journal   ReadQx 

Endoscopy

No-touch endoscopic full-thickness resection technique matches the surgical concept as far as possible.

Pubmed   Journal   ReadQx 

Gastroenterology

Comments on "TSP-9: A Barrett's Esophagus Biomarker Better Than Pathologists?"

Pubmed   Journal   ReadQx 

Potential of Serum Glycoproteome Profiling in Prediction of Advanced Adenomas and Colorectal Carcinoma: Individual Heterogeneity Should be Taken into Account.

Pubmed   Journal   ReadQx 

Validation of the Distinct Entity "Chronic Pancreatitis Without Prior Acute Pancreatitis": Complementary Role of Population- and Clinic-Based Studies.

Pubmed   Journal   ReadQx 

Gastrointest Endosc

Is it necessary to explore modified peroral endoscopic myotomy strategies to prevent the occurrence of gastroesophageal reflux?

Pubmed   Journal   ReadQx 

Novel through-the-scope dual-action tissue clip for mucosal defect closure after endoscopic resection of large nonpedunculated colorectal lesions: a strong stimulus for multinational collaboration.

Pubmed   Journal   ReadQx 

Gut

Comparison of OLGA and OLGIM as predictors of gastric cancer in a Latin American population: the ECHOS Study.

Pubmed   Journal   ReadQx 

Dominant-negative effect of lactase missense variants: hetero-complex assembly with the wild-type enzyme impairs intracellular trafficking and digestive function.

Pubmed   Journal   ReadQx 

Efficacy of dupilumab in patients with prior exposure to topical steroids: facing second-line treatments for eosinophilic oesophagitis.

Pubmed   Journal   ReadQx 

Endoscopic mucosal resection for large non-pedunculated colorectal polyps: staying on track with a safe, effective and cost-efficient technique.

Pubmed   Journal   ReadQx 

Productive infection of primary human hepatocytes with SARS-CoV-2 induces antiviral and proinflammatory responses.

Pubmed   Journal   ReadQx 

J Hepatol

Changing from NAFLD to MASLD: Similar Prognosis of Unresectable Extrahepatic Gastrointestinal Cancer Under Chemotherapy between NAFLD and MASLD.

Pubmed   Journal   ReadQx 

Combined inhibition of Stat3 and Periostin synergistically protects mice against liver fibrosis.

Pubmed   Journal   ReadQx 

Enhancing HCC Recurrence Prediction after Liver Transplantation: from DCP plus AFP-L3 model to GALAD Score.

Pubmed   Journal   ReadQx 

Hepatic encephalopathy and survival after transjugular intrahepatic portosystemic shunt: Do spontaneous portosystemic shunts matter?

Pubmed   Journal   ReadQx 

Liver disease is a significant risk factor for cardiovascular outcomes - A UK Biobank study.

Pubmed   Journal   ReadQx 

Normal weight and central obesity as predictors of increased all-cause mortality in metabolic dysfunction associated steatotic liver disease.

Pubmed   Journal   ReadQx 

Reply letter to the letter to the editor entitled: "5-mthf enhances the portal pressure reduction achieved with propranolol in patients with cirrhosis: a randomized placebo-controlled trial: was an accurate statistical analysis performed?"

Pubmed   Journal   ReadQx 

Response to: A comment on "A multicenter randomized-controlled trial of nucleos(t)ide analogue cessation in HBeAg-negative chronic hepatitis B."

Pubmed   Journal   ReadQx 

SARS-CoV-2 anti-spike IgG antibodies are present in all liver transplant recipients after fifth vaccine dose.

Pubmed   Journal   ReadQx 

Unmet need in screening for hepatitis D virus: time to take action.

Pubmed   Journal   ReadQx 

Uric acid may serve as the sixth cardiometabolic criterion for defining MASLD.

Pubmed   Journal   ReadQx 

machine perfusion, randomized controlled trials, liver transplantation, immune cellsPerfusate immune cell profiling during machine perfusion - A new tool to link risk and immune response after liver transplantation?

Pubmed   Journal   ReadQx